Nihal S El-bialy

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The present study aimed to evaluate the association between whole body exposure to extremely low frequency magnetic field (ELF-MF) and genotoxic , cytotoxic hazards in brain and bone marrow cells of newborn rats. Newborn rats (10 days after delivery) were exposed continuously to 50 Hz, 0.5 mT for 30 days. The control group was treated as the exposed one(More)
Hepatitis C Virus (HCV) non-structural protein 3 (NS3) protease drug resistance poses serious challenges on the design of an effective treatment. Substrate Envelope Hypothesis, "the substrates of HCV NS3/4A protease have a consensus volume inside the active site called substrate envelope" is used to design potent and specific drugs to overcome this problem.(More)
The present study examines the therapeutic efficacy of the administration of low-dose cisplatin (cis) followed by exposure to extremely low-frequency magnetic field (ELF-MF), with an average intensity of 10 mT, on Ehrlich carcinoma in vivo. The cytotoxic and genotoxic actions of this combination were studied using comet assay, mitotic index (MI), and the(More)
The effects of continuous whole body exposure to extremely low frequency magnetic fields (ELF-MF) (50 Hz,0.5 mT for 30 days24 hrs) on cytogenecity, bone parameters and some hematological and biochemical parameters were evaluated.Male rats were exposed continuously to ELF-MF for a period of 30 days. The exposure effects were assessed by measurements of(More)
Based on the N-terminal hexapeptide product of hydrolysis (EDVVCC) at HCV NS5A/5B junction, three modified groups of compounds are built. The first group contains linear peptides while the second and third groups contain P1-P3 and P2-P4 macrocyclic structures, respectively. Quantitative Structure Activity Relationship (QSAR) characterization and docking(More)
The effects of continuous whole body exposure to extremely low frequency magnetic fields (ELF-MF) (50 Hz, 0.5 mT for 30 days 24 hrs) on cytogenecity, bone parameters and some hematological and biochemical parameters were evaluated.Male rats were exposed continuously to ELF-MF for a period of 30 days. The exposure effects were assessed by measurements of(More)
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