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The Society of Toxicologic Pathology convened a working group to evaluate current practices regarding organ weights in toxicology studies. A survey was distributed to pharmaceutical, veterinary, chemical, food/nutritional and consumer product companies in Europe, North America, and Japan. Responses were compiled to identify organs routinely weighed for(More)
The DynEmics Research Program is a collaborative effort by four University research groups to study the changes taking place in environmental management in Dutch businesses. The companies included in the study make up the program's business panel. The four studies focus on: the dynamics of the integration of environmental management in company strategy; the(More)
Retinal toxicity of chloroquine has been known for several years, but the mechanism(s) of toxicity remain controversial; some author support the idea that the binding of chloroquine to melanin pigments in the retinal pigmented epithelium (RPE) play a major toxic role by concentrating the drug in the eye. In our study, 12 albinos Sprague-Dawley (SD) and 12(More)
In the present study, we have examined by light and electron microscopy whether SL 82.0715, a polyamine site-directed N-methyl-D-aspartate (NMDA) antagonist, causes pathological changes in cerebrocortical neurons similar to those observed with NMDA receptor channel blockers in the rat brain. Dizocilpine (1, 2 and 5 mg.kg-1, s.c.) induced a dose-dependent(More)
The need better to understand the pathways of corporate greening was highlighted as a key research anecdotes, short case studies and cross-sectional analyses dominated the literature on business and environment. However, understanding the pathways of corporate greening implied a need to track organizational changes through repeated surveys or longitudinal(More)
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