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  • Nigel Ramsden, Jessica Perrin, +11 authors Carsten Hopf
  • Biology, Medicine
  • ACS chemical biology
  • 2011 (First Publication: 21 October 2011)
  • Leucine-rich repeat kinase-2 (LRRK2) mutations are the most important cause of familial Parkinson's disease, and non-selective inhibitors are protective in rodent disease models. Because of theirContinue Reading
  • Bianca Van Broeck, J-M Chen, +6 authors Adele Rowley
  • Chemistry, Medicine
  • British journal of pharmacology
  • 2011 (First Publication: 1 May 2011)
  • BACKGROUND AND PURPOSE γ-Secretase modulators represent a promising therapeutic approach for Alzheimer's disease (AD) because they selectively decrease amyloid β 42 (Aβ42), a particularly neurotoxicContinue Reading