Nigel R. Colterjohn

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Giant cell tumor of bone (GCT) is a destructive and potentially metastatic bone tumour in which the characteristic giant cells have classically been considered the culprits in bone destruction. However, the neoplastic element of the tumour consists of propagative osteoblast-like stromal cells that may play a role in bone resorption. The objectives of this(More)
Purpose. This paper describes the functional and oncologic outcome of 30 cases (in 29 patients) treated with limb-salvage surgery for localized soft tissue sarcoma (STS) or fibromatosis of the foot and ankle.Subjects. Patients were eligible for the study if they had a STS or fibromatosis in the distal one-third of the tibia or the foot such that ablative(More)
Resection of large lipomatous tumours in the subdeltoid region remains technically challenging due to the risk of injury to the axillary neurovascular bundle. We describe a novel deltoid release and reinsertion technique for resection of large lipomatous tumours of the sub-deltoid region and report the functional and oncologic outcomes of six patients who(More)
The purpose of this investigation was to evaluate the effects of bone morphogenetic protein-2 (BMP-2) and doxycycline on the in vitro differentiation of osteoprogenitor cells isolated from human femoral cancellous bone. The differentiation of osteoprogenitors into bone-forming osteoblasts was evaluated by alkaline phosphatase activity, osteocalcin gene(More)
A radioiodinated photoreactive enkephalin derivative, 125I(D-Ala2, p-N3-Phe4-Met5)enkephalin, was used to photoaffinity label the opioid receptor from the membranes of four mammalian brains (without cerebellum) and spinal cords. These included the cat, rabbit, guinea pig and mouse. The photolabeled membranes were analyzed by sodium dodecyl sulfate gel(More)
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