Nigel Perry

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Bioactivity-directed isolation work on the endemic New Zealand brown alga Perithalia capillaris, seeking anti-inflammatory compounds, led to a new bis-prenylated quinone ( 4). This compound inhibited superoxide production by human neutrophils in vitro (IC 50 2.1 microM), but was more potent at inhibiting proliferation of HL60 cells (IC 50 0.34 microM). Two(More)
A novel tyrolobibenzyl derivative, 1-->beta-D-apiosyl-beta-D-glucopyranosyl 4-[2-(4-hydroxyphenyl)ethyl]benzofuran-2-carboxylate 3 (tyrolobibenzyl D) was isolated from Scorzonera humilis L. and its structure established by mass spectrometry and 1D- and 2D-NMR spectroscopy. The biological activities of the new compound and related tyrolobibenzyls A-C (1-2,(More)
Inflammatory bowel disease (IBD) is a chronic relapsing disease. Genetic predisposition to the disease reduces an individual's capacity to respond appropriately to environmental challenges in the intestine leading to inappropriate inflammation. IBD patients often modify their diet to mitigate or reduce the severity of inflammation. Turmeric (Curcuma longa(More)
Hosting functional languages in object-oriented environments, such as the Java Virtual Machine and Microsoft's Common Language Infrastructure, so that they inter-operate well with other languages presents a number of problems. In this paper we introduce Mondrian, a functional language specifically designed for such environments, and describe the decisions(More)
Lanchester's Equations are one of the most misunderstood and misused models of combat, yet they remain in widespread use as the combat mechanism behind many simulation systems. Previous work by the author examined the impact of a fractal distribution of forces on Lanchester's theory of combat. The present work extends that examination to conceptual issues(More)
The Royal Australian Navy (RAN) plans to exploit advances in simulation technology to improve its team training through the use of Advanced Distributed Simulation (ADS). Existing shore-based human-in-the-loop training simulators will be linked to a tactical wargaming system to provide a sophisticated command team training environment. Legacy simulators are(More)