Nigel Kirkham

Jane L Armstrong2
Stuart Horswell2
Jonathan Lumsdon2
Sharon A Tooze2
Penny E Lovat2
2Jane L Armstrong
2Stuart Horswell
2Jonathan Lumsdon
2Sharon A Tooze
2Penny E Lovat
Learn More
The increase in reports of novel diseases in a wide range of ecosystems, both terrestrial and marine, has been linked to many factors including exposure to novel pathogens and changes in the global climate. Prevalence of skin cancer in particular has been found to be increasing in humans, but has not been reported in wild fish before. Here we report(More)
Retrospective formalin-fixed paraffin-embedded tissue was obtained from a cohort of 150 samples comprising 29 benign melanocytic naevi and 121 primary melanomas of AJCC disease stages I or II at the time of diagnosis and excision at the Royal Victoria Infirmary, Newcastle-upon-Tyne between January 2003 and May 2005. Ethical permission for the study was(More)
Accumulating evidence suggests autophagy, the principle catabolic process for lysosomal degradation of surplus macromolecules (Roy and Debnath 2010) is fundamental to tumourigenesis. Impaired autophagy results in accumulation of cellular breakdown products, increased oxidative stress and neoplastic transformation (Mathew et al. 2009); whilst efficient(More)
  • 1