In an investigation into the transformation of mossy ber input to Purkinje cell output in the cerebellar cortex, we have developed a network model including a sophisticated compartmental model of the Purkinje cell. Analysis and simulations demonstrated the need to include a large number of parallel bers (244,000) to obtain realistic Purkinje cell ring… (More)
NEOSIM is a new simulation framework addressed at building large scale and detailed models of the nervous system. Its essence is a set of interfaces and protocols that enable a plug and play architecture for incorporating existing simulation modules such as NEURON  and GENESIS  as well as future visualisation and data analysis modules. From the start… (More)
The design and applications of massively parallel computational models could lead to dramatic advances in the ability to automate complex tasks such as those found in artificial intelligence.
Editorial Recently-issued NIH policy statement and implementation guidelines (National Institutes of Health, 2003) promote the sharing of research data. While urging that " all data should be considered for data sharing " and " data should be made as widely and freely available as possible " the current policy requires only high-direct-cost (> US… (More)
There is significant interest amongst neuroscientists in sharing neuroscience data and analytical tools. The exchange of neuroscience data and tools between groups affords the opportunity to differently re-analyze previously collected data, encourage new neuroscience interpretations and foster otherwise uninitiated collaborations, and provide a framework… (More)
Schizophrenia is a highly heritable psychotic disorder. It has been suggested that deficits of the established state arise from abnormal interactions between brain regions. We sought to examine whether such connectivity abnormalities would be present in subjects at high genetic risk for the disorder. Functional connectivity analysis was carried out on… (More)
BACKGROUND Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS We studied young individuals with at least two relatives with the disorder. At baseline functional… (More)