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BACKGROUND Empiric circumferential pulmonary vein isolation (CPVI) has become the therapy of choice for drug-refractory atrial fibrillation (AF). Although results are suboptimal, it is unknown whether mechanistically-based strategies targeting AF drivers are superior. OBJECTIVES This study sought to determine the efficacy and safety of localized(More)
AIMS Disease management programs can reduce hospitalizations in high-risk heart failure (HF) patients, but generalizability to the population hospitalized for HF remains to be proven. We aimed to assess the effectiveness of a discharge and outpatient management program in a non-selected cohort of patients hospitalized for HF. METHODS AND RESULTS Patients(More)
BACKGROUND One of the co-morbidities frequently associated with morbid obesity is gastro-esophageal reflux disease (GERD), present in >50 % of morbidly obese individuals. We compared the anti-reflux effect of vertical banded gastroplasty (VBG) and Roux-en-Y gastric bypass (RYGBP), and their effect on esophageal function. METHODS 10 patients underwent VBG(More)
OBJECTIVES The aim of this paper was to study mechanisms of formation of fractionated electrograms on the posterior left atrial wall (PLAW) in human paroxysmal atrial fibrillation (AF). BACKGROUND The mechanisms responsible for complex fractionated atrial electrogram formation during AF are poorly understood. METHODS In 24 patients, we induced sustained(More)
Accurate risk stratification of heart failure patients is critical to improve management and outcomes. Heart failure is a complex multisystem disease in which several predictors are categorical. Neural network models have successfully been applied to several medical classification problems. Using a simple neural network, we assessed one-year prognosis in(More)
AIMS We evaluated the ability of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance (CMR) to identify acute new-onset heart failure (HF) with left ventricular systolic dysfunction (LVSD), whether or not in relation to underlying coronary artery disease (CAD), in patients with no clinical evidence of associated ischaemic(More)
AIMS Research on paroxysmal atrial fibrillation (AF) assumes that fibrillation induced by rapid pacing adequately reproduces spontaneously occurring paroxysmal AF in humans. We aimed to compare the spectral properties of spontaneous vs. induced AF episodes in paroxysmal AF patients. METHODS AND RESULTS Eighty-five paroxysmal AF patients arriving in sinus(More)
INTRODUCTION The indication and extent of axillary lymph node dissection in breast cancer remains open to controversy. MATERIALS AND METHOD In this context, a 20-year survival study has been made of 1600 breast cancer patients subjected during surgical treatment to systematic dissection of the acromiothoracic vascular pedicle together with the(More)
OBJECTIVES To assess the nutritional status of autonomous, non-institutionalized, elder adults in social centers by means of the MNA scale and to analyze their distribution according to socio-demographical variables: gender, age, civil status, living with other people, educational level, and rural/urban setting. METHODS Cross-sectional study performed in(More)
This study focuses on the coastal monitoring network established in the scope of WFD implementation. The objective of this network was to provide an ecological assessment of Valencian coastal waters. After three years, sufficient data had been collected to enable us to analyse and explore ways to increase the network's efficiency. A methodology was(More)