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To explore trends over time in admission prevalence and (risk-adjusted) mortality of critically ill haematological patients and compare these trends to those of several subgroups of patients admitted to the medical intensive care unit (medical ICU patients). A total of 1,741 haematological and 60,954 non-haematological patients admitted to the medical ICU(More)
OBJECTIVES To compare two temporal abstraction procedures for the extraction of meta features from monitoring data. Feature extraction prior to predictive modeling is a common strategy in prediction from temporal data. A fundamental dilemma in this strategy, however, is the extent to which the extraction should be guided by domain knowledge, and to which(More)
OBJECTIVE To determine the extent to which computerised decision support can improve concordance of multidisciplinary teams with therapeutic decisions recommended by guidelines. DESIGN Multicentre cluster randomised trial. PARTICIPANTS Multidisciplinary cardiac rehabilitation teams in Dutch centres and their cardiac rehabilitation patients. (More)
Sensitivity analysis is a method to investigate the effects of varying a model's parameters on its predictions. It was recently suggested as a suitable means to facilitate quantifying the joint probability distribution of a Bayesian belief network. This article presents practical experience with performing sensitivity analyses on a belief network in the(More)
Clinical decision support systems (CDSSs) differ from other health information systems in their aim to directly influence the decision-making behaviour of healthcare professionals. As a result, CDSSs face additional challenges with respect to user acceptance. The objective of this study was to investigate subjective usability of a guideline-based CDSS for(More)
AIMS To assess the effects of multi-disciplinary cardiac rehabilitation (CR) on survival in the full population of patients with an acute coronary syndrome (ACS) and patients that underwent coronary revascularization and/or heart valve surgery. METHODS AND RESULTS Population-based cohort study in the Netherlands using insurance claims database covering(More)
PURPOSE The MacNew health-related quality of life questionnaire is internationally used as a standard for psychosocial assessment in many cardiac rehabilitation centres. This study investigates its discriminating capacity between diagnostic disease categories, sex and age at entry (T1) and at the end (T2) of cardiac rehabilitation as well as the(More)
OBJECTIVES To evaluate the influence of choice of a prognostic model and the effect of customization of these models on league tables (i.e., rank-order listing) in which intensive care units (ICUs) are ranked by standardized mortality ratios using Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II, and(More)
OBJECTIVE To introduce the focus theme of Methods of Information in Medicine on Intelligent Data Analysis for Knowledge Discovery, Patient Monitoring and Quality Assessment. METHODS Based on two workshops on Intelligent Data Analysis in bioMedicine (IDAMAP) held in Washington, DC, USA (2010) and Bled, Slovenia (2011), six authors were invited to write(More)
OBJECTIVE To study posttraumatic stress disorder (PTSD) in parents after unexpected pediatric intensive care unit (PICU) treatment of their child and to identify risk factors for its development. METHOD Parents completed PTSD questionnaires 3 and 9 months (N = 190) after PICU treatment. Risk factors included pretrauma data, medical data, social(More)