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BACKGROUND Erythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated. We therefore studied in vivo effects of systemic erythropoietin exposure in human skeletal muscle. METHODOLOGY/PRINCIPAL FINDINGS The protocols involved 1) acute effects of a single bolus injection of(More)
BACKGROUND The highest prevalence of several cardiovascular disease risk factors including obesity, smoking and low physical activity level is observed in adults of low socioeconomic status. This study investigates whether tracking of body mass index and physical fitness from childhood to adolescence differs between groups of socioeconomic status.(More)
1 Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce. The objective of this study was to examine(More)
BACKGROUND More studies include multiple generations of the Actigraph activity monitor. So far no studies have compared the output including the newest generation and investigated the impact on the output of the activity monitor when enabling the low frequency extension (LFE) option. The aims were to study the responses of four generations (AM7164, GT1M,(More)
BACKGROUND Lipolysis is accelerated during the acute phase of inflammation, a process being regulated by pro-inflammatory cytokines (e.g. TNF-α), stress-hormones, and insulin. The intracellular mechanisms remain elusive and we therefore measured pro- and anti-lipolytic signaling pathways in adipocytes after in vivo endotoxin exposure. METHODS Eight(More)
BACKGROUND An increasingly passive life-style in the Western World has led to a rise in life-style related disorders. This is a major concern for all segments of society. The county council of the municipality of Svendborg in Denmark, created six Sport Schools with increased levels of suitable physical activities, which made it possible to study the health(More)
This paper proposes an analytical framework for performance evaluation of TCP (Transport Control Protocol) over adaptive wireless links. Specifically, we include adaptation of power, modulation format and error recovery strategy, and incorporate some features of wireless fading channels. This framework is then used to pursue joint optimization through(More)
A fundamental assumption of the tcp protocol is that packet losses indicate congestion on the network. This is a problem when using tcp over wireless links, because a noisy radio transmission may erroneously indicate congestion and thereby reduce the tcp sending rate. Two partial solutions, that improve the quality of the radio link, are power control and(More)
Tumor necrosis factor-a (TNF-a) has widespread metabolic actions. Systemic TNF-a administration, however, generates a complex hormonal and metabolic response. Our study was designed to test whether regional, placebo-controlled TNF-a infusion directly affects insulin resistance and protein breakdown. We studied eight healthy volunteers once with bilateral(More)