Niels Bjørndal

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In a 12-weeks double-blind study high dosage versus standard dosage haloperidol therapy was evaluated in 23 male, chronic schizophrenic inpatients. The patients were relatively treatment-resistant and, in spite of traditional neuroleptic medication, were characterized by a moderate to severe degree of illness. At the end of the trial the dose of haloperidol(More)
The behavioural effects of apomorphine and GABAergic drugs alone and in combination were studied in eight monkeys (Cercopithecus aethiops) showing behavioural supersensitivity to dopamine agonists after long-term haloperidol treatment. Apomorphine (0.1–0.5 mg/kg SC) produced an increase in locomotion, repetitive movements of head, limbs and trunk, oral(More)
Eight psychiatric patients with tardive dyskinesia (TD) were treated with single doses of the synthetic met-enkephalin analogue FK 33-824 (1, 2, and 3 mg IM) morphine (10 mg SC) and naloxone, an opiate receptor antagonist (0.8 mg IM). The drug effects were assessed by blind evaluation of randomly sequenced videotapes made before and during treatment. FK(More)
Nine chronic schizophrenic patients selected from three hospital departments were treated with flupentixol (orally and IV) and cis(Z)-flupentixol decanoate in Viscoleo (IM) in a three-phase pharmacokinetic study. Oral administration (single and repeated dosage) showed a relatively slow absorption with maximum serum concentration around 4 h after(More)
Tardive dyskinesia (TD), a syndrome of involuntary hyperkinetic movements, purportedly involves the development of dopamine (DA) receptor hypersensitivity following long-term receptor blockade with neuroleptic drugs. It has been proposed that througn a process of receptor hypersensitivity modification, TD can be treated by reversing the receptor(More)
In eight monkeys (Cercopithecus aethiops), previously treated with haloperidol for 4–14 months, we have examined the behavioral effect of: (1) methylphenidate vs apomorphine; (2) 4,5,6,7-tetrahydroisoxazolo-(5,4-c)-pyridin-3-ol (THIP, a GABA agonist) vs diazepam; and (3) THIP and diazepam in methylphenidate-induced behavior. Methylphenidate (0.5–5.0 mg/kg)(More)
All of the new consultations in the Copenhagen Municipal psychiatric outpatient department during a period of three month were registered. Out of these, 1,149 did not lead to admission of the patient. In 47% of these information about somatic condition was available and in 31% information about somatic disease was present. Were 21% of the 1,149 patients(More)
All of the patients admitted to the psychiatric inpatient department of the Municipal Hospital in Copenhagen during a period of three months were, on discharge, registered as regards somatic disease. 70% (95% confidence limits 66-75%) had somatic disease (38% of these were newly diagnosed). Treatment of these was carried out by the medical staff of the(More)