Nicolette van Duinen

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CONTEXT AND OBJECTIVE Fatigue and excessive sleepiness have been reported after treatment of nonfunctioning pituitary macroadenomas (NFMA). Because these complaints may be caused by disturbed nocturnal sleep, we evaluated objective sleep characteristics in patients treated for NFMA. DESIGN We conducted a controlled cross-sectional study. SUBJECTS AND(More)
CONTEXT Sporadic pheochromocytomas are detected by clinical signs and symptoms, whereas pheochromocytomas in patients with a known hereditary predisposition for these tumors are detected by repetitive screening for catecholamine excess. OBJECTIVE To document the clinical, biochemical, and pathological differences between patients with sporadic(More)
OBJECTIVE To evaluate the prevalence and rheumatological and radiological characteristics of arthropathy in patients after long-term cure of acromegaly in comparison with age-matched controls. DESIGN Case-control study. PATIENTS We compared 89 patients with adequate biochemical control of acromegaly (mean 14 years) and 67 age-matched controls. (More)
The carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas (HNP) may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing. This is a case–control study. This study was conducted in a tertiary referral center. We assessed fatigue, sleep, and exercise capacity in 74 HNP(More)
BACKGROUND Octreotide, a somatostatin analog, may be beneficial in the treatment of head and neck paragangliomas (HNPGLs). METHODS We conducted a nonblinded, prospective intervention study. During 1 year, patients received a monthly intramuscular injection of 30 mg octreotide. Pretreatment and posttreatment tumor volumes were assessed by MRI, urinary(More)
CONTEXT Patients with head-and-neck paragangliomas (HNPGL) are regularly screened for catecholamine excess. The clinical relevance of increased urinary secretion of 3-methoxytyramine is unclear in HNPGL. OBJECTIVE The aim of the study was to assess the prevalence and the clinical, biochemical, and radiological presentation of patients with HNPGL with(More)
BACKGROUND Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). 
 AIM To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL(More)
Mutations in four genes encoding subunits or cofactors of succinate dehydrogenase (SDH) cause hereditary paraganglioma and pheochromocytoma syndromes. Mutations in SDHB and SDHD are generally the most common, whereas mutations in SDHC and SDHAF2 are far less frequently observed. A total of 1045 DNA samples from Dutch paraganglioma and pheochromocytoma(More)
CONTEXT The majority of patients with head and neck paragangliomas (HNPGL) have biochemically silent tumours. Chromogranin A (CgA) is a tumour marker for neuroendocrine tumours. OBJECTIVE To assess the role of CgA as a tumour marker in patients with hereditary HNPGL. PATIENTS AND METHODS We included 95 consecutive patients with hereditary HNPGL for(More)
CONTEXT A substantial number of patients with head and neck paragangliomas (HNPGLs) have biochemically active tumors, evidenced by increased urinary excretion of catecholamines and metabolites, including 3-methoxytyramine (3MT). It is unclear whether plasma levels of these parameters are more sensitive to detect biochemical activity in HNPGL patients than(More)
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