Nicoletta Bianchi

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Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of lentiviral vectors to increase hemoglobin synthesis might vary in different patients.We generated lentiviral(More)
This paper presents the architecture of a holonic multi-agent system for rock art interpretation and discusses the results achieved within the " Indiana MAS " project. We show how the AgentSketch and the ImageRec holons belonging to the Indiana MAS, able to cope with hand drawn sketches and images respectively, have been tested in the domain of Mount Bego's(More)
MicroRNAs are a family of small noncoding RNAs regulating gene expression by sequence-selective mRNA targeting, leading to a translational repression or mRNA degradation. The oncomiR miR-221 is highly expressed in human gliomas, as confirmed in this study in samples of low and high grade gliomas, as well in the cell lines U251, U373 and T98G. In order to(More)
Several transcription factors (TFs) play crucial roles in governing the expression of different genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, oncogenesis, repair and fibrosis processes and inflammation. As far as inflammation, TFs playing pivotal roles are nuclear factor kappa B (NF-kB),(More)
The objective of this review is to present examples of lead compounds identified from biological material (fungi, plant extracts and agro-industry material) and of possible interest in the field of a pharmacological approach to the therapy of beta-thalassemia using molecules able to stimulate production of fetal hemoglobin (HbF) in adults. Concerning the(More)
With the invention and rapid improvement of data-capturing devices, such as satellite imagery and digital cameras, the information that archaeologists must manage in their everyday's activities has rapidly grown in complexity and amount. In this work we present Indiana Finder, an interactive visualization system that supports archaeologists in the(More)
This paper presents the first results achieved within the In-diana MAS project funded by Italian Ministry for Education, University and Research, MIUR. We discuss how the AgentSketch holon belonging to the Indiana MAS has been extended to cope with images, besides hand drawn sketches, and has been tested in the domain of Mount Bego's prehistoric rock art(More)
Two transcripts of the human estrogen receptor (ER) gene have been described, ER mRNA 1 and mRNA 2, different in their 5' untranslated region. By performing reverse transcriptase-polymerase chain reaction with oligonucleotides specific for the 5' genomic region of the human ER gene we have identified a new ER RNA transcript. The sequence analysis of cDNA(More)
BACKGROUND Cystic fibrosis (CF) airway pathology is a fatal, autosomal, recessive genetic disease characterized by extensive lung inflammation. After induction by TNF-α, elevated concentrations of several pro-inflammatory cytokines (i.e. IL-6, IL-1β) and chemokines (i.e. IL-8) are released from airway epithelial cells. In order to reduce the excessive(More)
Gene therapy might fall short in achieving a complete reversion of the β-thalassemic phenotype due to current limitations in vector design and myeloablative regimen. Following gene transfer, all or a large proportion of erythroid cells might express suboptimal levels of β-globin, impairing the therapeutic potential of the treatment. Our aim was to evaluate(More)