Nicoletta Bianchi

Monica Borgatti12
Ilaria Lampronti9
Cristina Zuccato9
12Monica Borgatti
9Ilaria Lampronti
9Cristina Zuccato
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Several transcription factors (TFs) play crucial roles in governing the expression of different genes involved in the immune response, embryo or cell lineage development, cell apoptosis, cell cycle progression, oncogenesis, repair and fibrosis processes and inflammation. As far as inflammation, TFs playing pivotal roles are nuclear factor kappa B (NF-kB),(More)
The objective of this review is to present examples of lead compounds identified from biological material (fungi, plant extracts and agro-industry material) and of possible interest in the field of a pharmacological approach to the therapy of beta-thalassemia using molecules able to stimulate production of fetal hemoglobin (HbF) in adults. Concerning the(More)
This paper presents the first results achieved within the In-diana MAS project funded by Italian Ministry for Education, University and Research, MIUR. We discuss how the AgentSketch holon belonging to the Indiana MAS has been extended to cope with images, besides hand drawn sketches, and has been tested in the domain of Mount Bego's prehistoric rock art(More)
A series of 18-mer peptide nucleic acids (PNAs) targeted against micro-RNA miR-210 was synthesised and tested in a cellular system. Unmodified PNAs, R(8) -conjugated PNAs and modified PNAs containing eight arginine residues on the backbone, either as C2-modified (R) or C5-modified (S) monomers, all with the same sequence, were compared. Two different models(More)
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of lentiviral vectors to increase hemoglobin synthesis might vary in different patients.We generated lentiviral(More)
With the invention and rapid improvement of data-capturing devices, such as satellite imagery and digital cameras, the information that archaeologists must manage in their everyday's activities has rapidly grown in complexity and amount. In this work we present Indiana Finder, an interactive visualization system that supports archaeologists in the(More)
The β-thalassemias are a group of hereditary hematological diseases caused by over 300 mutations of the adult β-globin gene. Together with sickle cell anemia, thalassemia syndromes are among the most impactful diseases in developing countries, in which the lack of genetic counseling and prenatal diagnosis have contributed to the maintenance of a very high(More)
This paper presents the Indiana Ontology for modeling the knowledge about Mount Bego's rock art and its exploitation in the IndianaMAS project. Although many projects use ontologies for semantic processing of cultural heritage digital objects, we are not aware of such ontologies in the rock art domain. Also, the Indiana Ontology is fully and seamlessly(More)
Gene therapy might fall short in achieving a complete reversion of the β-thalassemic phenotype due to current limitations in vector design and myeloablative regimen. Following gene transfer, all or a large proportion of erythroid cells might express suboptimal levels of β-globin, impairing the therapeutic potential of the treatment. Our aim was to evaluate(More)
BACKGROUND Cystic fibrosis (CF) airway pathology is a fatal, autosomal, recessive genetic disease characterized by extensive lung inflammation. After induction by TNF-α, elevated concentrations of several pro-inflammatory cytokines (i.e. IL-6, IL-1β) and chemokines (i.e. IL-8) are released from airway epithelial cells. In order to reduce the excessive(More)