Nicole Wilken

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A partial cDNA clone coding for the mouse homologue of the human Ran-GTP binding protein, RanBP2, has been isolated by screening of a murine expression library with antibodies to nup180, a previously identified nuclear pore complex protein (nucleoporin). Whether the antibodies cross-reacted with the polypeptide encoded by the cDNA clone or, alternatively,(More)
Using an autoimmune serum from a patient with overlap connective tissue disease we have identified by biochemical and immunocytochemical approaches an evolutionarily conserved nuclear pore complex (NPC) protein with an estimated molecular mass of 180 kD and an isoelectric point of approximately 6.2 which we have designated as nup180. Extraction of isolated(More)
Import of DNA from the cytoplasm into the mitochondrial matrix is an obligatory step for an in organello site-directed mutagenesis or gene therapy approach on mitochondrial DNA diseases. In this context, we have developed an artificial DNA translocation vector that is composed of the mitochondrial signal peptide of the ornithine transcarbamylase (OTC) and a(More)
Screening and monitoring in men prescribed testosterone therapy in the U.S., 2001–2010. J Baillargeon, RJ Urban, YF Kuo, HM Holmes, MA Raji, A Morgentaler, BT Howrey, YL Lin, KJ Ottenbacher. PublicHealth Rep 2015;130:143–52. Editorial Comment: Testosterone therapy for late-onset hypogonadism is a controversial practice. What is not controversial is the need(More)
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