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A reversed-phase HPLC method is described for the simultaneous determination of folinic acid, MTX, and their plasma metabolites 5-CH3−FH4 and 7-OH-MTX respectively. In addition, this technique allows the separation of FA another naturally occurring folate, and of AMT, used as internal standard. Separation of these compounds was achieved on a Waters(More)
PURPOSE This outpatient multicenter trial tested the hypothesis that subcutaneous administration of an interleukin-2 (IL-2)/interferon alfa (IFN alpha) combination produces a response rate greater than 20% in patients with renal cell carcinoma (RCC). PATIENTS AND METHODS Patients with metastatic RCC received a 12-week induction treatment with subcutaneous(More)
Twenty-six patients (median age 33 years) with poor-risk malignancies were treated with high-dose combination chemotherapy associating BCNU-etoposide-cytosine arabinoside and melphalan (BEAM) followed by autologous bone marrow transplantation (ABMT). Twenty-one patients had malignant lymphomas, three, acute lymphoblastic leukemia (ALL), and two, malignant(More)
Eleven adult patients with poor-risk non-Hodgkin's lymphoma were treated with high-dose melphalan (140 mg/m2) or high-dose combination chemotherapy (BCNU, Ara-C, vindesine and melphalan) followed by autologous bone marrow transplantation. Six of the eight patients evaluable for response achieved complete remission and one achieved partial remission.(More)
Etoposide and cisplatinum have used separately to treat refractory lymphomas. This report describes 22 patients in whom these two agents were used in conjunction. All had been extensively treated with standard therapies previously. The combination of etoposide and cisplatinum was chosen on the basis of preclinical evidence for synergy and because these(More)
Sex steroid hormones such as testosterone and oestradiol induce immunomodulation of the and cytosolic binding has been demonstrated in normal and pathological human lymphocytes, (Danel et al., 1981). How the hormones enter the cells is controversial: a "passive" diffusion as described by Peck et al. (1973) or a "facilitated" diffusion as postulated by(More)
Steroid binding to human lymphocytes was previously detected by a fluorescence assay (Tubiana et al., 1984). In the present study fluorescence assays were carried out with a macromolecular complex constituted by covalently binding steroid to bovine serum albumin (BSA). In this way it was possible to eliminate transmembrane diffusion and confine the study to(More)
s of Posters EXTRACTIVE BIOCATALYSIS IN A TWO-LIQUID-PHASE SYSTEM WITH PLANT CELL SUSPENSIONS Lucilla Bassetti, Johannes Tramper Extractive fermentation is a technique used to reduce end product inhibition by removing the fermentation products in situ. The extraction can be performed by using an organic/aqueous two-phase system if the organic phase(More)
The level of circulating thymic factor (FTS) tested by its action on spleen rosette-forming cells from adult thymectomized mice, has been shown to be stable in young animals. This stability suggests a regulatory mechanism. An approach of this regulation has been attempted by disrupting the FTS level either by neonatal thymus grafting in adult normal and(More)