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  • Gérard Lescoat, Karine Chantrel-Groussard, Nicole Pasdeloup, Hanspeter Nick, Pierre Brissot, François Gaboriau
  • Biology, Medicine
  • Cell proliferation
  • 2007 (First Published: 1 October 2007)
  • OBJECTIVE Iron loading has been observed to have a hyperproliferative effect on hepatocytes in vitro and on tumour cells in vivo; removal of this iron being required to induce antitumour activity. Continue Reading
  • Isabelle Morel, Gérard Lescoat, Josiane Cillard, Nicole Pasdeloup, Pierre Brissot, Pierre Cillard
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1990 (First Published: 1 June 1990)
  • The present study relates to the effect of ferric iron supplementation on lipid peroxidation of adult rat hepatocyte pure cultures. Lipid peroxidation was evaluated by free malondialdehyde (MDA)Continue Reading
  • Karine Chantrel-Groussard, François Gaboriau, +5 authors Gérard Lescoat
  • Chemistry, Medicine
  • European journal of pharmacology
  • 2006 (First Published: 1 July 2006)
  • By comparing the antiproliferative effect of the iron chelators ICL670A and O-trensox in the human hepatoma cell line HUH7 and human hepatocyte cultures, we have shown that ICL670A decreased cellContinue Reading
  • Odile Sergent, J. P. Anger, Gérard Lescoat, Nicole Pasdeloup, Pierre Cillard, Josiane Cillard
  • Chemistry, Medicine
  • Cellular and molecular biology
  • 1997 (First Published: 1 July 1997)
  • Electron paramagnetic resonance (EPR) has been described as suitable for the evaluation of low molecular weight (LMW) iron in liver homogenates after chelation by desferrioxamine. LMW iron is aContinue Reading
  • Isabelle Morel, Josiane Cillard, +6 authors Pierre Cillard
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1992 (First Published: 1 November 1992)
  • The protective effect on iron-supplemented hepatocyte cultures of three iron chelators, pyoverdin Pa and hydroxypyrid-4-one derivatives CP20 and CP22, was compared to that of the widely knownContinue Reading
  • Isabelle Morel, Odile Sergent, +5 authors Josiane Cillard
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1995 (First Published: 1 February 1995)
  • Iron supplementation of hepatocyte culture induced the production of lipid-derived radicals as shown by spin-trapping with alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN). The EPR signalContinue Reading