Nicole P. Leahy

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Among mammals, genetic recombination occurs at highly delimited sites known as recombination hotspots. They are typically 1-2 kb long and vary as much as a 1,000-fold or more in recombination activity. Although much is known about the molecular details of the recombination process itself, the factors determining the location and relative activity of(More)
Coevolution is the process of mutual adaptation of two populations. When a difficult optimization is performed with evolutionary computation, a population of adaptive test cases can strongly affect the progress of evolution. This study applies coevolution to the Tartarus task, a grid robot test problem. If the coevolving test cases are viewed as a form of(More)
The iterated prisoner’s dilemma is a widely used computational model of cooperation and conflict. Many studies report emergent cooperation in populations of agents trained to play prisoner’s dilemma with an evolutionary algorithm. This study varies the representation of the evolving agents resulting in levels of emergent cooperation ranging from 0% to over(More)
HLA-A, -B, -C, -DRB1, -DQB1 assignments were obtained for 374 pairs of African American mothers and their umbilical cord blood units (CBU) by DNA sequencing. An algorithm developed by the National Marrow Donor Program was used to assign 1122 haplotypes by segregation. Seventy percent of the haplotypes carried assignments at all five loci. In the remainder,(More)
Genetic matching for loci in the human leukocyte antigen (HLA) region between a donor and a patient in hematopoietic stem cell transplantation (HSCT) is critical to outcome; however, methods for HLA genotyping of donors in unrelated stem cell registries often yield results with allelic and phase ambiguity and/or do not query all clinically relevant loci. We(More)
The success of high resolution genetic mapping of disease predisposition and quantitative trait loci in humans and experimental animals depends on the positions of key crossover events around the gene of interest. In mammals, the majority of recombination occurs at highly delimited 1-2 kb long sites known as recombination hotspots, whose locations and(More)
Game theoretic models are often used to simulate phenomena observed in the natural world. It is generally assumed that the implementation (or representation) of the agents within a game has no significant effect on the outcome of simulations. To test this assumption the effect of changing the representation of agents in the nonreciprocal cooperation game(More)
This report describes the project to identify the global distribution of extended HLA haplotypes, a component of 16th International HLA and Immunogenetics Workshop (IHIW), and summarizes the initial analyses of data collected. The project aims to investigate extended HLA haplotypes, compare their distribution among different populations, assess their(More)