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BACKGROUND Recent studies have demonstrated the existence of circulating mitochondrial DNA in plasma and serum, but the concentrations and physical characteristics of circulating mitochondrial DNA are unknown. The aim of this study was to develop an assay to quantify mitochondrial DNA in the plasma of healthy individuals. METHODS We adopted a real-time(More)
BACKGROUND At present there is no simple, accurate blood test that may be used to determine the severity of stroke or to predict mortality and morbidity in stroke patients presenting to emergency departments. METHODS Patients with stroke-like symptoms who presented to an emergency department of a university hospital in Hong Kong were recruited for the(More)
BACKGROUND Cell-free DNA concentrations increase in the circulation of patients after trauma and may have prognostic potential, but little is know concerning the temporal changes or clearance of the DNA or its relationships with posttraumatic complications. We investigated temporal changes in plasma DNA concentrations in patients after trauma with use of(More)
BACKGROUND Acute coronary syndrome may involve cell death and the release of nucleic acids into the circulation. We thus investigated whether plasma DNA concentrations are increased and determined its prognostic significance in patients with ACS. METHODS Real-time polymerase chain reaction was used to quantitatively measure the beta-globin gene from blood(More)
With the increasing popularity of storing content on the WWW and intranet in XML form, there arises the need for the control and management of this data. As this data is constantly evolving, users want to be able to query previous versions, query changes in documents, as well as to retrieve a particular document version efficiently. This paper proposes a(More)
This paper presents an efficient content-based version management system for managing XML documents. Our proposed system uses complete deltas for the logical representation of document versions. This logical representation is coupled with an efficient storage policy for version retrieval and insertion. Our storage policy includes the conditional storage of(More)
Modern neuroimaging safely and reliably diagnoses stroke and provides information for outcome prediction. However, some patients with clinical stroke have no detectable abnormality on neuroimaging and other patients are not fit for such investigations. Therefore, we evaluated the potential of plasma DNA and serum S100 protein concentrations to predict(More)