Nicole L Werner

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BACKGROUND Fluoroquinolones are among the most commonly prescribed antimicrobials and are an important risk factor for colonization and infection with fluoroquinolone-resistant gram-negative bacilli and for Clostridium difficile infection (CDI). In this study, our aim was to determine current patterns of inappropriate fluoroquinolone prescribing among(More)
2 Past work examining the effects of interruption complexity on primary task performance has yielded quite mixed results. Some research suggests that more complex interruptions lead to greater disruption of the primary task, while other studies have shown that interruption complexity does not directly influence the amount of primary task disruption. It is(More)
When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates(More)
Xanthophyllomyces dendrorhous is a basidiomycetous yeast that synthesizes astaxanthin, a carotenoid with great biotechnological impact. The ergosterol and carotenoid synthetic pathways derive from the mevalonate pathway and involve cytochrome P450 enzymes. Among these enzymes, the CYP51 family, which is involved in ergosterol biosynthesis, is one of the(More)
Since its introduction to neurosurgery in 2008, laser ablative techniques have been largely confined to the management of unresectable tumors. Application of this technology for the management of focal epilepsy in the adult population has not been fully explored. Given that nearly 1,000,000 Americans live with medically refractory epilepsy and current(More)
Dieses Projekt wurde als Teil einer von der Deutschen Forschungsgemeinschaft (DFG) geförderten Längsschnittstudie über soziale Aggression unter Schülern (SCHA 747/3-1) durchgeführt. Abstract Studies of children who are the frequent targets of peers' aggressive acts have been guided by two differing research traditions, namely the " bully/victim " and the "(More)
The basidiomycetous yeast Xanthophyllomyces dendrorhous has been described as a potential biofactory for terpenoid-derived compounds due to its ability to synthesize astaxanthin. Functional knowledge of the genes involved in terpenoid synthesis would create opportunities to enhance carotenoid production. A thiolase enzyme catalyzes the first step in(More)
To explore Candida guilliermondii for the production of long-chain dicarboxylic acids (DCA), we performed metabolic pathway engineering aiming to prevent DCA consumption during β-oxidation, but also to increase its production via the ω-oxidation pathway. We identified the major β- and ω-oxidation pathway genes in C. guilliermondii and performed first steps(More)
The market for industrial enzymes is increasing steadily. Hence, efficient expression systems and processes for the large-scale production of industrial enzymes are of common interest. The presented article deals with the recombinant production of a fungal lipase in yeasts, and with its large-scale, fermentative production up to 1.000 Litres.
OBJECTIVE Selective amygdalohippocampectomy (AHC) has evolved to encompass a variety of techniques to resect the mesial temporal lobe. To date, there have been few large-scale evaluations of trans-middle temporal gyrus selective AHC. The authors examine a large series of patients who have undergone the trans-middle temporal gyrus AHC and assess its clinical(More)