Nicole Kaiser

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The aim of this study was to investigate possible effects of ionizing irradiation on the electrophysiological functionality of cardiac myocytes in vitro. Primary chicken cardiomyocytes with spontaneous beating activity were irradiated with X-rays (dose range of 0.5-7 Gy). Functional alterations of cardiac cell cultures were evaluated up to 7 days after(More)
Ionizing radiation (IR) exerts deleterious effects on the developing brain, since proliferative neuronal progenitor cells are highly sensitive to IR-induced DNA damage. Assuming a radiation response that is comparable to mammals, the chick embryo would represent a lower vertebrate model system that allows analysis of the mechanisms underlying this(More)
Irradiation is widely used to treat brain tumors, and also to create bone marrow (BM) chimeras. BM chimeras are widely used to dissect functions and origin of microglia and blood-derived mononuclear cells under homeostatic or pathological conditions. This is facilitated by the fact that microglia survive irradiation and are thus regarded radio-resistant. In(More)
receptor complex sedimenting at 4 to 5 S. When incubated at 37°,the high-salt buffer extracted bound radioactivity that sedimented at ~4 S. There was some residual bound radioactivity sedimenting as a broad peak at 5 to 8 S in the low-salt extract after 30 min of incubation at 37°; however, additional bound radioactivity which sedimented at ~4 S could be(More)
Nasal mucosa and olfactory bulb are separated by the cribriform plate which is perforated by olfactory nerves. We have previously demonstrated that the cribriform plate is permissive for T cells and monocytes and that viruses can enter the bulb upon intranasal injection by axonal transportation. Therefore, we hypothesized that nasal mucosa and olfactory(More)
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