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A Novel Molecular Solution for Ultraviolet Light Detection in Caenorhabditis elegans
It is shown that C. elegans strongly accelerates its locomotion in response to blue or shorter wavelengths of light, with maximal responsiveness to ultraviolet light, which is mediated by LITE-1, a novel ultraviolet light receptor that acts in neurons and is a member of the invertebrate Gustatory receptor (Gr) family. Expand
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
- S. Edwards, Nicole K. Charlie, J. Richmond, J. Hegermann, S. Eimer, K. Miller
- Biology, Medicine
- The Journal of cell biology
- 21 September 2009
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Sumakovic et al.… Expand
Presynaptic UNC-31 (CAPS) Is Required to Activate the Gαs Pathway of the Caenorhabditis elegans Synaptic Signaling Network
- Nicole K. Charlie, Michael A Schade, Angela M Thomure, K. Miller
- Biology, Medicine
- 1 February 2006
The data suggest that presynaptic UNC-31 activity, likely acting via dense-core vesicle exocytosis, is required to locally activate the neuronal Gαs pathway near synaptic active zones. Expand
Trio’s Rho-specific GEF domain is the missing Gαq effector in C. elegans
Results show that Trio’s Rho-specific GEF domain is a major Gq effector that, together with PLC, mediates the Gq signaling that drives the locomotion, egg laying, and growth of the animal. Expand
Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.
Using cell-based and biochemical assays, it is shown that activated C. elegans Galpha(q) synergizes with Trio RhoGEF to activate RhoA and appears to be part of a signaling complex, because they coimmunoprecipitate when expressed together in cells. Expand
The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network.
The genetic analysis suggests that PDE-4 regulates both Galpha(s)-dependent and G alpha(s-independent cAMP pools in the neurons controlling locomotion rate, and immunostaining suggests that it may exert its effects by spatially regulating intrasynaptic cAMP swimming pools. Expand
The Dunce cAMP Phosphodiesterase PDE-4 Negatively Regulates Gαs-Dependent and Gαs-Independent cAMP Pools in the Caenorhabditis elegans Synaptic Signaling Network
The genetic analysis suggests that PDE-4 regulates both G αs-dependent and Gαs-independent cAMP pools in the neurons controlling locomotion rate and that it may exert its effects by spatially regulating intrasynaptic cAMP swimming pools. Expand