Nicole K Phillips

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This study used longitudinal, multimethod data to examine specific patterns of behavioral interaction with parents and peers that were hypothesized to predict increasing levels of depressive symptoms in early adolescence. Adolescents' struggles in establishing autonomy and relatedness in interactions with mothers, and a withdrawn, angry, or dependent(More)
The current study was a prospective exploration of the specificity of early childhood adversities as predictors of anxiety and depressive disorders in adolescents. Participants were 816 adolescents (414 males, 402 females) with diagnostic information collected at age 15; information on early adversities had been collected from the mothers during pregnancy,(More)
OBJECTIVE To describe the effect of HIV on white matter integrity and neurocognitive function in children vertically infected with HIV, compared to a HIV-negative healthy control group. DESIGN Cross-sectional. METHODS We compared 75 HIV-infected children aged 6-16 years, including children on antiretroviral therapy (ART) and those who were ART-naive,(More)
One of the most serious consequences of vertical HIV-infection is its impact on the central nervous system (CNS). Although much work has been done to elucidate the complex mechanism of HIV associated neurotoxicity, several questions remain unanswered. The purpose of this review is to summarise what is already known in the field of neuroimaging in vertically(More)
The South African endemic plant Sceletium tortuosum has a long history of traditional use as a masticatory and medicine by San and Khoikhoi people and subsequently by European colonial farmers as a psychotropic in tincture form. Over the past decade, the plant has attracted increasing attention for its possible applications in promoting a sense of wellbeing(More)
CONTEXT Research shows, conclusively, that perinatal HIV infection has negative effects on cognitive functioning of children and adolescents. However, the extent of these cognitive impairments is unknown. Current literature does not document specific cognitive domains most affected in HIV-infected children and adolescents. OBJECTIVE To systematically(More)
In rodents, the endogenous opioid system has been implicated in emotion regulation, and in the reduction of fear in particular. In humans, while there is evidence that the opioid antagonist naloxone acutely enhances the acquisition of conditioned fear, there are no corresponding data on the effect of opioid agonists in moderating responses to fear. We(More)
A range of factors contributes to white matter damage in vertically infected HIV-positive children. These may include combination antiretroviral treatment (cART) regimen, sociodemographic factors, nutritional–hematological status, HIV-relevant clinical variables, and cognitive functioning. We explored associations between a number of these factors and(More)
In the present research, an animal model was developed to ascertain the potential effects of gestational drug concentrations and/or maternal seizures on the neonate. The rhesus monkey (Macaca mulatta) was the species of choice as previous research has demonstrated its validity as a model for partial epilepsy. Phenytoin (PHT) was tested because it is(More)
PURPOSE A monkey (Macaca fascicularis) model was previously used to assess infant hyperexcitability after prenatal exposure to phenytoin (PHT), stiripentol (STP) or PHT+STP. To explore this issue further, we studied additional monkey infants in those groups, as well as groups prenatally exposed to carbamazepine (CBZ) in monotherapy (n = 5) or CBZ+STP(More)