Nicole Burchardi

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BACKGROUND Of the newer antiepileptic drugs, lamotrigine (LTG) and levetiracetam (LEV) are popular first choice drugs for epilepsy. The authors compared these drugs with regard to their efficacy and tolerability in the initial monotherapy for epilepsy. METHODS A randomised, open-label, controlled, parallel group, multicenter trial was conducted to test(More)
Patients suffering from amyotrophic lateral sclerosis (ALS) eventually lose their ability to communicate their treatment preferences in later stages of the disease. A living will enables ALS patients to specify their choices concerning life-sustaining treatment in advance. Our premise was that completion of a living will should be preceded by a discussion(More)
BACKGROUND Non-inferiority and equivalence trials require tailored methodology and therefore adequate conduct and reporting is an ambitious task. The aim of our review was to assess whether the criteria recommended by the CONSORT extension were followed. METHODS We searched the Medline database and the Cochrane Central Register for reports of randomised(More)
  • Taxane–Anthracycline Containing, Chemotherapy—DAFNE GBG, +16 authors Gunter von Minckwitz
  • 2015
Purpose: Dual anti-HER2 blockade with trastuzumab/pertu-zumab or trastuzumab/lapatinib in combination with anthra-cycline/taxane–based chemotherapy can reach pathologic complete response (pCR) rates of up to 60% in HER2-positive breast cancer. The DAFNE (Dual blockade with AFatinib and trastuzumab as NEoadjuvant treatment) phase II study (NCT015591477)(More)
Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastases (BMs) were collected retrospectively in four centers(More)
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