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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD usingExpand
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Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala
Chronic alcohol consumption and withdrawal leads to anxiety, escalated alcohol drinking behavior, and alcohol dependence. Alterations in the function of key structures within the cortico-limbicExpand
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Chronic alcohol produces neuroadaptations to prime dorsal striatal learning
Significance Alcoholism is characterized by a progressive degradation of executive control and an increase in compulsive alcohol seeking that is hypothesized to involve a shift from prefrontal cortexExpand
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Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward
The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid receptor (KOR) systemExpand
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Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.
Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, weExpand
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Neuropeptide Regulation of Signaling and Behavior in the BNST
Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long rangeExpand
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Chronic alcohol alters rewarded behaviors and striatal plasticity
Chronic intermittent ethanol (CIE) alters neural functions and behaviors mediated by the dorsolateral striatum (DLS) and prefrontal cortex. Here, we examined the effects of prolonged (16‐bout) CIE onExpand
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Chronic stress dysregulates amygdalar output to the prefrontal cortex
ABSTRACT Chronic stress contributes to the neuropathology of mental health disorders, including those associated with anxiety. The basolateral amygdala (BLA) coordinates emotional behavioralExpand
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Adolescent Social Stress Increases Anxiety-like Behavior and Alters Synaptic Transmission, Without Influencing Nicotine Responses, in a Sex-Dependent Manner
Early-life stress is a risk factor for comorbid anxiety and nicotine use. Because little is known about the factors underlying this comorbidity, we investigated the effects of adolescent stress onExpand
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In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons
Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlyingExpand
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