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- Publications
- Influence
Corneal Transduction by Intra-Stromal Injection of AAV Vectors In Vivo in the Mouse and Ex Vivo in Human Explants
- Claire Hippert, Sandy Ibanes, +4 authors V. Kalatzis
- Biology, Medicine
- PloS one
- 16 April 2012
The cornea is a transparent, avascular tissue that acts as the major refractive surface of the eye. Corneal transparency, assured by the inner stroma, is vital for this role. Disruption in stromal… Expand
The Ocular Anomalies in a Cystinosis Animal Model Mimic Disease Pathogenesis
- V. Kalatzis, Nicolas Serratrice, +9 authors E. Kremer
- Biology, Medicine
- Pediatric Research
- 1 August 2007
Cystinosis is a lysosomal storage disorder characterized by abnormal accumulation of cystine, which forms crystals at high concentrations. The causative gene CTNS encodes cystinosin, the lysosomal… Expand
Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human Dendritic Cells: Implications for Clinical Efficacy
- M. Perreau, Franck J. D. Mennechet, +4 authors E. Kremer
- Biology, Medicine
- Journal of Virology
- 17 January 2007
ABSTRACT Antipathogen immune responses create a balance between immunity, tolerance, and immune evasion. However, during gene therapy most viral vectors are delivered in substantial doses and are… Expand
Cystine accumulation in the CNS results in severe age-related memory deficits
- T. Maurice, Claire Hippert, Nicolas Serratrice, Grégor Dubois, V. Kalatzis
- Chemistry, Medicine
- Neurobiology of Aging
- 1 June 2009
Cystinosis is a lysosomal storage disorder characterised by progressive cystine accumulation. The causative gene, CTNS, encodes cystinosin, the lysosomal cystine transporter. Neurological… Expand
Corrective GUSB transfer to the canine mucopolysaccharidosis VII brain.
- Aurélie Cubizolle, Nicolas Serratrice, +14 authors E. Kremer
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 1 April 2014
Severe deficiency in lysosomal β-glucuronidase (β-glu) enzymatic activity results in mucopolysaccharidosis (MPS) VII, an orphan disease with symptoms often appearing in early childhood. Symptoms are… Expand
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.
- N. Mestre-Francés, Nicolas Serratrice, +15 authors E. Kremer
- Biology, Medicine
- JCI insight
- 25 July 2018
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key… Expand
Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector.
- Nicolas Serratrice, Aurélie Cubizolle, +11 authors E. Kremer
- Biology, Medicine
- Journal of controlled release : official journal…
- 10 May 2014
Corneal transparency is maintained, in part, by specialized fibroblasts called keratocytes, which reside in the fibrous lamellae of the stroma. Corneal clouding, a condition that impairs visual… Expand
Achilles tendinopathy recovery after a single autologous PRP injection monitored by ultrasound
- A. Silvestre, A. Peuchant, Olivier Bausset, J. Magalon, G. Magalon, Nicolas Serratrice
- Medicine
- 1 June 2014
Abstract Background Achilles tendinopathy remains often chronic and rebel to a thorough conservative treatments. In this context, autologous platelet-rich plasma (PRP) could represent an interesting… Expand
Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice.
- L. Ariza, L. Giménez‐Llort, +8 authors A. Bosch
- Biology, Medicine
- Human gene therapy
- 1 March 2014
Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous system (CNS) disorders because of their preferential transduction of neurons and efficient retrograde… Expand
Cns Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type Vii Mice
- L. Ariza, L. Giménez‐Llort, +8 authors A. Bosch
- Medicine
- 2013
Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous system (CNS) disorders due to their preferential transduction of neurons and efficient retrograde axonal… Expand
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