Nicolas Rouleau

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If structure dictates function within the living human brain, then the persistence of specific responses to weak electric currents in fixed, deceased brains could reflect "hardwired" properties. Different key structures from the left and right hemispheres of brains that had been fixed for over 20years with ethanol-formalin-acetic acid were stimulated with(More)
Covering the heads of human volunteers with a toque lined with copper mesh compared to no mesh resulted in significant diminishments in quantitative electroencephalographic power within theta and beta-gamma bands over the right caudal hemisphere. The effect was most evident in women compared to men. The significant attenuation of power was verified by(More)
The structure of the post-mortem human brain can be preserved by immersing the organ within a fixative solution. Once the brain is perfused, cellular and histological features are maintained over extended periods of time. However, functions of the human brain are not assumed to be preserved beyond death and subsequent chemical fixation. Here we present a(More)
Structural imaging tools can be used to identify neuropathology in post-mortem tissue whereas functional imaging tools including quantitative electroencephalography (QEEG) are thought to be restricted for use in living subjects. We are not aware of any study which has used electrophysiological methods decades after death to infer pathology. We therefore(More)
Post-mortem human neural tissues fixed in ethanol and aldehyde-based solutions express modulated frequency-dependent microvolt potentials when probed by chemical and electrical stimuli. These observations run contrary to the assumption that basic tissue functions are irreversibly impaired upon fixation, in the absence of nutrients and sufficient(More)
Synthetic experimental substrates are indispensable tools which can allow researchers to model biological processes non-invasively in three-dimensional space. In this study, we investigated the capacities of an electroconductive material whose properties converge upon those of the brain. An electrically conductive material composed of carbohydrates,(More)
An archaeoacoustic study was recently conducted within the prehistoric cave system of El Castillo in northern Spain. With findings dating back at least 40800 years, archaeological studies of this cave have revealed the presence of prehistoric ritual activity associated with early shamanism. Simulated audio tones of varying frequencies were created and(More)
Within a cell system structure dictates function. Any interaction between cells, or a cell and its environment, has the potential to have long term implications on the function of a given cell and emerging cell aggregates. The structure and function of cells are continuously subjected to modification by electrical and chemical stimuli. However, biological(More)
Vaccines based on conserved pneumococcal proteins are being investigated because serotype coverage by pneumococcal polysaccharide and polysaccharide conjugate vaccines is incomplete and may eventually decrease due to serotype replacement. Here, we examined the functionality of human antibodies induced by a candidate bivalent choline-binding protein A-(More)
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