Learn More
OBJECTIVE To test the performance of the head-impulse and caloric tests in terms of sensitivity, specificity, and predictive efficiency. STUDY DESIGN This was an open and prospective study conducted at a tertiary care center in which 265 patients were subjected to the head-impulse test and caloric test on the same day. The results of the head-impulse test(More)
OBJECTIVE To perform a transcultural adaptation form English to Spanish of two common questionnaires of handicap assessment in vestibular disorders. STUDY DESIGN Prospective study. PATIENTS 337 patients seen for non-acute dizziness from peripheral or central origin in a tertiary referral setting. MAIN OUTCOME MEASURES Dizziness Handicap Inventory test(More)
Different surveys have been carried out on the plasma activities of different glycosidases in patients with insulin-dependent diabetes mellitus, but research on urinary glycosidases in this disease is scanty and incomplete. To elucidate the behavior of these lysosomal enzymes in the metabolic alterations occurring in the glomerular basal membrane during the(More)
Previous animal research and clinical experiences in humans suggest the existence of an auditory critical period in language acquisition. We review the literature and present the changes within the cochlear nuclei in bilaterally deafferentated adult non-human primates. We also present and analyse the results of 98 prelingually deaf children and teenagers(More)
Toll-like receptors trigger the innate immune response by activating various cell types such us macrophages and lymphocytes. We genotyped SNV of TLR3, TRL7, TLR8 and TLR10 in 863 Spanish and 150 Italian patients with Meniere’s disease (MD) and 1,013 controls by using Taqman assays. Real-Time qPCR was used to measure the expression level of TLR10 in(More)
Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of(More)
OBJECTIVE The vestibular autorotation test (VAT) examines the ocular response to voluntary horizontal and vertical head movements at frequencies for which the vestibular system is the main source for eye stabilization. The purpose of this study was to analyse the VAT results in patients with disabling Ménière's disease and to evaluate the change in VAT(More)
OBJECTIVE We sought to correlate the severity of vertigo and handicap in patients with vestibular pathology according to measures of impairment. STUDY DESIGN AND SETTING We conducted a prospective assessment of patients with dizziness by means of caloric, rotatory test, and computerized dynamic posturography to estimate impairment. Handicap and severity(More)
A mother and two of her daughters had deafness and cortical reflex myoclonus; the mother also had mild truncal ataxia. Muscle and skin biopsy specimens revealed abundant ragged-red fibres and abnormal mitochondria. The son of one of the daughters had sensorineural deafness. Three other grandchildren were asymptomatic. The two daughters also had diabetes(More)