Nicolas Levasseur

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Hyaluronan (HA) has different biological functions according to its molar mass; short HA fragments are involved in inflammation processes and angiogenesis, whereas native HA is not. Physicochemically, studies of native HA hydrolysis catalyzed by bovine testicular hyaluronidase (HAase) have suggested that kinetic parameters depend on HA chain length. To(More)
Weighted Constraint Satisfaction Problems (WCSP) are used to model and to solve some constraint optimization problems. WCSPs are often solved by complete or partial tree search strategies combined with filtering. For these methods, variable ordering heuristic (MinDom/FutDeg) and value ordering heuristic (MinAC) are considered to be the most efficient ones.(More)
Hyaluronidase (HAase) plays an important role in the control of the size and concentration of hyaluronan (HA) chains, whose biological properties strongly depend on their length. Our previous studies of HA hydrolysis catalyzed by testicular HAase demonstrated that, whilst the substrate-dependence curve has a Michaelis-Menten shape with a 0.15 mol L(-1)(More)
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