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In the landscape of cloud computing, the competition between providers has led to an ever growing number of cloud solutions offered to consumers. The ability to run and manage multi-cloud systems (i.e., applications on multiple clouds) allows exploiting the peculiarities of each cloud solution and hence optimising the performance, availability, and cost of(More)
The market of cloud computing encompasses an ever-growing number of cloud providers offering a multitude of infrastructure-as-a-service (IaaS) and platform-as-a-service (PaaS) solutions. The heterogeneity of these solutions hinders the proper exploitation of cloud computing since it prevents interoperability and promotes vendor lock-in, which increases the(More)
Dynamically adaptive systems (DAS) enable the continuous design and adaptation of complex software systems, but their main focus is limited to the application itself rather than the underlying platform and infrastructure. Cloud computing, in contrast, enables the management of the complete software stack, but it lacks integration with software engineering(More)
OBJECTIVE A defect of the lysosomal enzyme alpha-L-iduronidase (IDUA) interrupts the degradation of glycosaminoglycans in mucopolysaccharidosis type I, causing severe neurological manifestations in children with Hurler's syndrome. Delivery of the missing enzyme through stereotactic injection of adeno-associated virus vectors coding for IDUA prevents(More)
BACKGROUNDS AND AIMS When hepatocyte proliferation is impaired, liver regeneration proceeds from the division of non parenchymal hepatocyte progenitors. Oval cells and Small Hepatocyte-like Progenitor Cells (SHPCs) represent the two most studied examples of such epithelial cells with putative stem cell capacity. In the present study we wished to compare the(More)
Vendor lock-in and cloud outages are two important challenges that make IT managers reluctant in widely adopting the cloud within the enterprise. Vendor lock-in happens when the adoption of cloud provider-specific technologies and APIs forces consumers to stay with the same provider even if they would like to change. Cloud outages can happen to any(More)
Our works on software architectures for highly dynamic environments , such as ubiquitous computing, led us to consider models at runtime. Indeed, the biggest challenge of these environments is adaptation , and its reactivity is a key concern. In this paper, we describe models of our dynamic service composition and adaptation approach, and the benefits of(More)
  • By P. BRASSEUR, P. BAHUREL, +11 authors J. VERRON
  • 2009
SUMMARY During the past 15 years, a number of initiatives have been undertaken at national level to develop ocean forecasting systems operating at regional and/or global scales. The coordination between these efforts has been organized internationally through the Global Ocean Data Assimilation Experiment (GODAE). The French MERCATOR project is one of the(More)
Tianeptine is a new antidepressant drug reported to enhance serotonin (5-hydroxytryptamine [5-HT]) uptake in rat brain. The effect of tianeptine on 5-HT platelet uptake was studied in 10 depressed patients treated for 28 days. Tianeptine increases Vmax of 5-HT platelet uptake during treatment without inducing any change in Km. As early as 2 hr after the(More)