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Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications.
TLDR
Mass spectrometry can identify thiol modifications with precision, and with isotope-coded affinity tags, used to quantify modification of specific thiols, and combinations of these methods increase sensitivity and specificity, and enable quantification and precise identification of thiol modification that occur under physiological and pathological conditions. Expand
S-Glutathiolation of p21ras by Peroxynitrite Mediates Endothelial Insulin Resistance Caused by Oxidized Low-Density Lipoprotein
TLDR
This study provides direct evidence for a novel molecular mechanism by which oxidants can induce insulin resistance via S-glutathiolation of p21ras and Erk-dependent inhibition of insulin signaling. Expand
S‐glutathiolation by peroxynitrite of p21ras at cysteine‐118 mediates its direct activation and downstream signaling in endothelial cells
TLDR
It is shown that peroxynitrite added exogenously or generated endogenously in response to exposure to an NO donor or oxidized low‐density lipoproteins (oxLDL) increases p21ras activity in bovine aortic endothelial cells. Expand
(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism.
TLDR
The results demonstrate that renin and prorenin, through their specific membrane receptor and independently of angiotensin II, promote fibrosis gene expression via a Nox4-dependent mechanism. Expand
Mechanisms of the vasorelaxing effects of CORM-3, a water-soluble carbon monoxide-releasing molecule: interactions with eNOS
TLDR
CO can produce concomitantly activation and inhibition of NO synthase, the former being responsible for the endothelium- and cGMP-dependent effect of CORM-3, the latter for the inhibition of acetylcholine-induced endothelia-dependent relaxations. Expand
Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry.
TLDR
The quantitative changes in thiol modification caused by GSSG associated with increased activity demonstrate the potential importance of redox modulation of p21ras. Expand
KCa3.1 channels maintain endothelium‐dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS
TLDR
The purpose of the study was to investigate renal endothelium‐dependent vasodilatation in a model of severe hypertension associated with kidney injury and found it to be a safe and effective treatment for kidney injury. Expand
Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure
TLDR
KCa2/3 channels play a major role in the regulation of murine kidney perfusion and this mechanism is maintained in hypertension, even when severe and associated with kidney damage. Expand
Detailed map of oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry.
TLDR
High-resolution and high mass accuracy Fourier transform mass spectrometry was utilized to map, in detail, the post-translational modifications of p21ras (H-ras) exposed to oxidants by combining bottom-up and top-down techniques. Expand
Polyamine modulation of iron uptake in CHO cells.
TLDR
It is demonstrated that the cell polyamine transport system is a potential cell entry pathway for iron, and the studied polyamines, spermine and spermidine, may be components of the pool of transferrin-independent iron-chelating vectors, which have recently attracted the attention of many investigators. Expand
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