Nicolas Boussion

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UNLABELLED PET allows the imaging of functional properties of the living tissue, whereas other modalities (CT, MRI) provide structural information at significantly higher resolution and better image quality. Constraints for injected radioactivity, technologic limitations of current instrumentation, and inherent spatial uncertainties on the decaying process(More)
PURPOSE Positron Emission Tomography (PET) has the unique capability of measuring brain function but its clinical potential is affected by low resolution and lack of morphological detail. Here we propose and evaluate a wavelet synergistic approach that combines functional and structural information from a number of sources (CT, MRI and anatomical(More)
UNLABELLED The display of image fusion is well accepted as a powerful tool in visual image analysis and comparison. In clinical practice, this is a mandatory step when studying images from a dual PET/CT scanner. However, the display methods that are implemented on most workstations simply show both images side by side, in separate and synchronized windows.(More)
Accurate volume contouring in PET is crucial for quantitation in numerous oncology applications. The objective of our study was to compare the performance of two algorithms for automatic lesion volume delineation that permit noise modelling and have not previously been applied to PET data; namely the Hidden Markov Chains (HMC) model and a novel version:(More)
UNLABELLED Whole-brain activity is often chosen to quantitatively normalize peri-ictal and interictal SPECT scans before their subtraction. This use is not justified, because significant and extended modification of the cerebral blood flow can occur during a seizure. We validated and compared 2 automatic methods able to determine the optimal reference(More)
PURPOSE Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography leading to underestimation of uptake in tissues of size similar to the point spread function (PSF) of the scanner as well as activity spillover between adjacent structures. Among PVE correction methodologies, a voxel-wise mutual multiresolution(More)
The spatial resolution in emission tomography induces partial volume effects, leading to underestimation of the real uptake and activity spillover. They can be corrected using either region of interest or voxel based approaches. We developed a voxel wise correction, based on the wavelet transform of two co-registered images in order to insert high(More)
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