Nicolas Arnaud

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UNLABELLED BACKGROUND Mid to late adolescence is characterised by a vulnerability to problematic substance use since the consumption of alcohol and illicit drugs is frequently initiated and increased in this life period. While the detrimental long- and short-term effects of problematic consumption patterns in adolescence pose a major public health(More)
INTRODUCTION The increasing number of children and adolescents in need of emergency medical treatment following acute alcohol intoxication has been a major public health concern in Europe in recent years. However, little is known about drinking habits and associated risks in this population. To our knowledge, this is the first study to examine drinking(More)
OBJECTIVES The proportion of children and adolescents receiving emergency care for acute alcohol intoxication (AAI) in Germany has sharply increased over the past years. Despite this, no randomized controlled trials (RCTs) have studied guideline- and evidence-based interventions to prevent future alcohol misuse within this population. The objective of our(More)
BACKGROUND Alcohol misuse among youth is a major public health concern and numbers of adolescents admitted to the emergency department for acute alcoholic intoxication in Germany are recently growing. The emergency setting offers an opportunity to reach at-risk alcohol consuming adolescents and provide brief interventions in a potential "teachable moment".(More)
BACKGROUND The purpose of this study is to evaluate the effects of a German adaptation of the Strengthening Families Programme 10-14 (SFP 10-14; Familien Stärken). METHODS A multi-centre randomised controlled trial comparing the German SFP version consisting of seven sessions and four booster-sessions with a minimal intervention on parenting as control(More)
BACKGROUND Mid-to-late adolescence is a critical period for initiation of alcohol and drug problems, which can be reduced by targeted brief motivational interventions. Web-based brief interventions have advantages in terms of acceptability and accessibility and have shown significant reductions of substance use among college students. However, the evidence(More)
Interaktive Bildschirmmedien sind weit verbreitet und führen bei einem Teil der Nutzer zu einem pathologischen Gebrauch, der phänomenologisch deutliche Ähnlichkeiten zu Suchterkrankungen aufweist. Zu unterscheiden sind dabei die suchthafte Nutzung von Computerspielen und weiterer Internetaktivitäten wie die Nutzung sozialer Netzwerke. In der Vergangenheit(More)
OBJECTIVES Testing the effectiveness of a brief motivational intervention in an emergency-setting for adolescents with acute alcohol intoxication in a randomized-controlled trial and sustained implementation within mental health care of Hamburg. METHODS Modification and evaluation of an established indicated prevention program in a transdisciplinary(More)
INTRODUCTION The CRAFFT questionnaire is a widely utilized measure of problematic alcohol and drug use. The brief screening instrument has been translated into multiple languages, and some studies regarding its psychometric properties have been published. However, investigations on the factorial validity of the CRAFFT in a clinical sample are not available(More)
While c-Myc dysregulation is constantly associated with highly proliferating B-cell tumors, nuclear factor (NF)-κB addiction is found in indolent lymphomas as well as diffuse large B-cell lymphomas, either with an activated B-cell like phenotype or associated with the Epstein-Barr virus. We raised the question of the effect of c-Myc in B cells with NF-κB(More)