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UNLABELLED BACKGROUND Mid to late adolescence is characterised by a vulnerability to problematic substance use since the consumption of alcohol and illicit drugs is frequently initiated and increased in this life period. While the detrimental long- and short-term effects of problematic consumption patterns in adolescence pose a major public health(More)
BACKGROUND Alcohol misuse among youth is a major public health concern and numbers of adolescents admitted to the emergency department for acute alcoholic intoxication in Germany are recently growing. The emergency setting offers an opportunity to reach at-risk alcohol consuming adolescents and provide brief interventions in a potential "teachable moment".(More)
OBJECTIVES The proportion of children and adolescents receiving emergency care for acute alcohol intoxication (AAI) in Germany has sharply increased over the past years. Despite this, no randomized controlled trials (RCTs) have studied guideline- and evidence-based interventions to prevent future alcohol misuse within this population. The objective of our(More)
BACKGROUND Mid-to-late adolescence is a critical period for initiation of alcohol and drug problems, which can be reduced by targeted brief motivational interventions. Web-based brief interventions have advantages in terms of acceptability and accessibility and have shown significant reductions of substance use among college students. However, the evidence(More)
BACKGROUND The purpose of this study is to evaluate the effects of a German adaptation of the Strengthening Families Programme 10-14 (SFP 10-14; Familien Stärken). METHODS A multi-centre randomised controlled trial comparing the German SFP version consisting of seven sessions and four booster-sessions with a minimal intervention on parenting as control(More)
Interaktive Bildschirmmedien sind weit verbreitet und führen bei einem Teil der Nutzer zu einem pathologischen Gebrauch, der phänomenologisch deutliche Ähnlichkeiten zu Suchterkrankungen aufweist. Zu unterscheiden sind dabei die suchthafte Nutzung von Computerspielen und weiterer Internetaktivitäten wie die Nutzung sozialer Netzwerke. In der Vergangenheit(More)
BACKGROUND Increasing numbers of youth in need of emergency medical treatment following alcohol intoxication have been a major public health concern in Europe in recent years. Brief interventions (BIs) in the emergency department (ED) could prevent future risky drinking. However, effectiveness and feasibility of this approach are currently unclear. METHOD(More)
While c-Myc dysregulation is constantly associated with highly proliferating B-cell tumors, nuclear factor (NF)-κB addiction is found in indolent lymphomas as well as diffuse large B-cell lymphomas, either with an activated B-cell like phenotype or associated with the Epstein-Barr virus. We raised the question of the effect of c-Myc in B cells with NF-κB(More)
Environmental resources (e.g., air quality, water quantity) are needed to understand fundamental questions such as global change. Such resources are often collected from sensors, including humans acting as sensors. Tools have emerged to manage such data in the form of time series and, in particular, the Sensor Observation Service (SOS) which offers a(More)
While the effectiveness of substance use prevention programs such as the Strengthening Families Program 10–14 (SFP) has been demonstrated in the USA, European SFP adaptations have not replicated these sizable effects. Following the rationale of the risk moderation hypothesis positing that elevated risk groups may benefit more from a preventive intervention(More)