Nicolai I Yegorenkov

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Atomic force microscopy (AFM) has recently provided the great progress in the study of micro- and nanostructures including living cells and cell organelles. Modern AFM techniques allow solving a number of problems of cell biomechanics due to simultaneous evaluation of the local mechanical properties and the topography of the living cells at a high spatial(More)
The morphology and structure of erythrocyte cytoskeleton and local mechanical characteristics in patients with type 2 diabetes mellitus and donors were studied by atomic force microscopy. Poikilocytosis and anisocytosis, spatial reorganization of the cytoskeleton (loosening and condensation of the actin-spectrin network), and modification of local(More)
Atomic force microscopy (AFM) was used to study surface layers of fixed intact erythrocytes. Advantages of simultaneous analysis of surface topography and lateral force maps in the investigation of cytoskeleton structure were shown. Fractal analysis was applied to the lateral force maps of erythrocyte surfaces to evaluate the complexity of the cytoskeleton.(More)
The changes in passive ion permeability of the red blood cell membrane after peroxynitrite action (3 microM-3 mM) have been studied by biophysical (using radioisotopes of rubidium, sodium and sulphur (sulphate)) and electrophysiological methods. The enhancement of passive membrane permeability to cations (potassium and sodium ions) and the inhibition of(More)
Peroxynitrite is formed in the organism by activated neutrophils as a result of the enhanced production of nitrogen monoxide and superoxide anion radical in the inflammation foci. Since peroxynitrite modifies the structure of macromolecules, including the elements of actin cytoskeleton, it can influence signal transduction pathways that regulate(More)
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