Overdose of acetaminophen (APAP) causes severe centrilobular hepatic necrosis in humans and experimental animals. Here, to explore its mechanism, we administered APAP at subtoxic (150 mg/kg ip) and toxic (500 mg/kg ip) doses to overnight fasted mice. Animals were sacrificed at different time points from 15 min to 4 h postinjection. We assessed liver… (More)
The inappropriate exposure to endocrine disruptors continues to be a significant, as well as controversial, health issue (Colborn et al., 1993, Safe, 2000). While early emphasis was often placed on examples of environmental exposure, more recent concerns have focused on endocrine active potential and potency of commercial products and formulations, both… (More)
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1. A new fusion gene NUP98-IQCG identified in an acute… (More)
A granular cell tumour presenting within the spinal cord of a 17-year-old woman is described. This distinctive tumour has a widespread distribution, but has been reported only rarely in the central nervous system. The literature is reviewed.