Nicola Parolini

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Driven by the commercial success of recombinant biopharmaceuticals, there is an increasing demand for novel mammalian cell culture bioreactor systems for the rapid production of biologicals that require mammalian protein processing. Recently, orbitally shaken bioreactors at scales from 50 mL to 1,000 L have been explored for the cultivation of mammalian(More)
Benchmark configurations for quantitative validation and comparison of incompressible interfacial flow codes, which model two-dimensional bubbles rising in liquid columns, are proposed. The benchmark quantities: circularity, center of mass, and mean rise velocity are defined and measured to monitor convergence towards a reference solution. Initial studies(More)
In the last two decades, the level set method has been extensively used for the numerical solution of interface problems in different domains. The basic idea is to embed the interface as the level set of a regular function. In this paper we focus on the numerical solution of interface advection equations appearing in free-surface fluid dynamics problems,(More)
Most of the biopharmaceuticals nowadays are produced by animal cells. The worldwide demand for a specific group of biopharmaceuticals, the monoclonal antibodies (mAbs), has significantly increased this last decade. The mAbs are used as therapeutics in particular against cancer and autoimmune disorders. Most of the mAbs are produced as recombinant proteins(More)
The numerical simulation of free-surface flows around sailing boats is a complex topic that addresses multiple mathematical tasks: the correct study of the flow field around a rigid hull, the numerical simulation of the hull dynamics, the deformation of the sails and appendages under transient external conditions like gusts of wind or wave patterns and,(More)
Ionic wind devices or electrostatic fluid accelerators are becoming of increasing interest as tools for thermal management, in particular for semiconductor devices. In this work, we present a numerical model for predicting the performance of such devices, whose main benefit is the ability to accurately predict the amount of charge injected at the corona(More)
The problem of link prediction has recently received increasing attention from scholars in network science. In social network analysis, one of its aims is to recover missing links, namely connections among actors which are likely to exist but have not been reported because data are incomplete or subject to various types of uncertainty. In the field of(More)
Mammalian cell cultures have become a major topic of research in the biopharmaceutical industry. This kind of cells require specific conditions to grow. In this thesis, we study the hydrodynamics of orbitally shaken reactors (OSR), a recently introduced kind of bioreactors for mammalian cell cultures that represents a simple to operate and cheap alternative(More)
Researches on green data centers have defined guidelines and end-to-end methodologies to increase energy efficiency. Most of these approaches require a disrupting reengineering of the infrastructure and significant upfront investments. Smaller data centers need to reach green objectives with a more incremental approach. The EnergIT project proposes a(More)
Introduction: Retroperitoneum is the third most common extragonadal site for occurrence of teratoma in children, after sacrococcygeal region and gonadal sites. Although many authors have previously reported laparoscopic removal of benign retroperitoneal teratoma in adults, the experience in pediatric setting is extremely limited. Material and methods: We(More)
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