Nicola J. Croxall

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BACKGROUND Epigenetic reprogramming is critical for genome regulation during germ line development. Genome-wide demethylation in mouse primordial germ cells (PGC) is a unique reprogramming event essential for erasing epigenetic memory and preventing the transmission of epimutations to the next generation. In addition to DNA demethylation, PGC are subject to(More)
Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s2/i2 form of VacA colonized mice more(More)
and follow-up studies to determine their mechanism of action. We anticipate that the use of small molecules will not only improve our ability to manipulate ES/iPS cells for drug discovery and regenerative medicine, but also generate useful chemical tools for basic cell and developmental biology research. While adult neurogenesis in mammals is mainly(More)
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