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The Causes and Consequences of Topological Stress during DNA Replication
The faithful replication of sister chromatids is essential for genomic integrity in every cell division. The replication machinery must overcome numerous difficulties in every round of replication,Expand
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Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress
Summary DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNAExpand
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Checkpoint inhibition of origin firing prevents DNA topological stress.
A universal feature of DNA damage and replication stress in eukaryotes is the activation of a checkpoint-kinase response. In S-phase, the checkpoint inhibits replication initiation, yet the functionExpand
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Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress
Abstract The highly conserved Tof1/Timeless proteins minimise replication stress and promote normal DNA replication. They are required to mediate the DNA replication checkpoint (DRC), the stableExpand
Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress
The highly conserved Tof1/Timeless proteins minimise replication stress and promote normal DNA replication. They are required to mediate the DNA replication checkpoint (DRC), the stable pausing ofExpand
DNA topological stress during DNA replication in Saccharomyces cerevisiae
DNA topological stress impedes normal DNA replication. If topological stress is allowed to build up in front of the replication fork, the fork rotates to overcome the stress, leading to formation ofExpand