Nicola Cesari

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Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R). Recent evidence in pre-clinical models points toward a putative dichotomic role of the two receptors, with OX2R predominantly involved in the regulation of the sleep/wake cycle and(More)
The computing cluster built at Bologna to provide the LHCb Collaboration with a powerful Monte Carlo production tool is presented. It is a performance oriented Beowulf-class cluster, made of rack mounted commodity components, designed to minimize operational support requirements and to provide full and continuous availability of the computing resources. In(More)
The importance of evaluating drug metabolism and pharmacokinetic (DMPK) properties very early in the drug discovery process in order to reduce attrition during development is now well recognised. In this paper we illustrate an approach for PK screening that provides a range of parameters that would not be available from conventional PK profiling. In(More)
Amphetamines are a group of sympathomimetic drugs that exhibit strong central nervous system stimulant effects. D-Amphetamine ((+)-alpha-methylphenetylamine) is the parent drug in this class to which all others are structurally related. In drug discovery, d-amphetamine is extensively used either for the exploration of novel mechanisms involving the(More)
The relation between the branching ratios and direct CP asymmetries of B → Kπ decays and the angle γ of the CKM unitarity triangle is studied numerically in the general framework of the SU(3) approach, with minimal assumptions about the parameters not fixed by flavour-symmetry arguments. Experimental and theoretical uncertainties are subjected to a(More)
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