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Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or unknown subtle environmental perturbations. These factors can induce a pronounced artifactual correlation(More)
MOTIVATION Genomic studies have revealed a substantial heritable component of the transcriptional state of the cell. To fully understand the genetic regulation of gene expression variability, it is important to study the effect of genotype in the context of external factors such as alternative environmental conditions. In model systems, explicit(More)
In this paper, we discuss the design and engineering of a biologically-inspired, host-based intrusion detection system to protect computer networks. To this end, we have implemented an Artificial Immune System (AIS) that mimics the behavior of the biological adaptive immune system. The proposed AIS, consists of a number of running artificial white blood(More)
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