Nicolò Malagutti

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The problem of automatic administration of vasoactive drugs to regulate mean arterial pressure in surgical and postsurgical patients can be considered as a setpoint tracking problem involving a system which is characterised by significant modelling uncertainty in the form of uncertain parameters, unmodelled dynamics and disturbances. Yet, specific levels of(More)
Automatic closed-loop administration of sodium nitroprusside for the regulation of blood pressure in patients experiencing acute hypertension has been the subject of intense research over the last three decades. Yet, to date, manual administration of vasoactive drugs by a human operator remains the standard of care in the clinical setting. This manuscript(More)
Automatic administration of medicinal drugs has the potential of delivering benefits over manual practices in terms of reduced costs and improved patient outcomes. Safe and successful substitution of a human operator with a computer algorithm relies, however, on the robustness of the control methodology, the design of which depends, in turn, on available(More)
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