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MOTIVATION Establishing phospholipid identities in large lipidomic datasets is a labour-intensive process. Where genomics and proteomics capitalize on sequence-based signatures, glycerophospholipids lack easily definable molecular fingerprints. Carbon chain length, degree of unsaturation, linkage, and polar head group identity must be calculated from mass(More)
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The persistence of a depressive episode in coronary artery disease (CAD) patients not only heightens the risk of acute ischemic events, but it is also associated with accelerated cognitive decline. Antidepressant interventions for depression in CAD have only modest effects and novel approaches are limited by a poor understanding of etiological mechanisms.(More)
Our capacity to model human disease through genetic manipulation has made the mouse (Mus musculus) one of the most important entities in bio-medicine. Transgenic and targeted genetic mouse models of neurodegenerative disease are typically engineered on a mixed background of inbred mouse lines, i.e., 129/Sv and C57BL/6. These inbred strains display(More)
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