Niclas Lindqvist

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Long-term selection (> 45 generations) for low or high body weight from the same founder population has generated two extremely divergent lines of chickens, the low (LWS) and high weight (HWS) lines, which at the age of selection (56 days) differs by more than nine-fold in body weight. The HWS line chickens are compulsive feeders, whereas, in the LWS line,(More)
PURPOSE To test whether Müller glial cells sense, and respond to, mechanical tension in the retina. METHODS A device was designed to stretch the retina at right angles to its surface, across retinal layers. Pieces of retina were mounted between two hollow tubes, and uniaxial force was applied to the tissue using a micrometer-stepping motor. Müller cells(More)
It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days after pretreatment for 2 weeks with the glucocorticoid,(More)
The "vasoconstrictor" effect of dermally applicated steroids is a widely used parameter when determining the potency of glucocorticoids. A similar effect on the nasal mucosa has been suggested as providing an explanation for the clinical effect of topically administered glucocorticoids in the treatment of nasal disorders such as allergic and vasomotor(More)
Experiments were performed both in the laboratory and a desulfurization pilot unit in order to improve the SiC-FET sensor performance using two-step data evaluation. In both cases, a porous Pt-gate enhancement type SiC-FET was utilized in a temperature cycled operation (TCO). Liner Discriminant Analysis (LDA) was chosen as the method for multivariate data(More)
Budesonide has been used for a number of years as a topical nasal corticosteroid in the treatment of nasal allergy and nasal polyps. Recently, a new device for powder insufflation where no constituents or preservatives are included has been developed (Rhinocort Turbuhaler, Astra Draco AB, Sweden). The present investigation was designed in order to study the(More)
During the last decade topical glucocorticoids have been established as the first hand choice for the treatment of allergic rhinitis. Although they are clinically effective, their precise mode of action has not been sufficiently clarified. In order to evaluate whether the clinical effect is dependent on the topical administration a randomized, double-blind,(More)
A double-blind parallel trial of budesonide versus placebo was carried out in 19 patients suffering from nasal polyposis. The patients were randomly assigned to two groups, one receiving a daily dose of 400 micrograms of budesonide and the other a corresponding dose of placebo intranasally for 4 months. The total mean symptom scores and nasal peak flow(More)
All 112 patients aged 80 and above treated at the intensive care unit at the University Hospital in Lund, Sweden 1994-1995 were followed-up retrospectively in terms of six-month survival (SMS) and for survivors in terms of quality of life. Overall SMS was the same for both men and women--47%. Patients with the poorest SMS were those aged 90 and above with(More)
The clinical effects of intranasal budesonide (16 alpha, 17 alpha (22 R,S) propylmethylenedioxypregana-1-4-diene-11beta 21 diol-3, 20 dione)) - a new non-halogenated glucocorticoid - were evaluated in a double-blind comparison with placebo, in patients with pronounced hay fever. Aerosolized budesonide, using a daily dosage of either 400 microgram or 200(More)