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BACKGROUND Potentially inappropriate prescribing (PIP) in older people has been identified as a substantial problem, but few large population-based studies have investigated the underlying factors that predict it. OBJECTIVE To: (i) examine trends in PIP in UK older primary care patients; and (ii) assess factors associated with PIP. METHODS An analysis(More)
PURPOSE To examine trends in UK primary care prescribing of medications potentially inappropriate for older people in the context of published international data. METHODS Analysis of routinely collected anonymised computerised patient records in 131 UK general practices (approximately 162,000 registered patients annually aged >or=65 years) providing data(More)
BACKGROUND Type 2 diabetes is an important cause of morbidity and mortality. Its prevalence appears to be increasing. Guidelines exist regarding its management. Recommendations regarding drug therapy have changed. Little is known about the influence of these guidelines and changed recommendations on the actual management of patients with type 2 diabetes.(More)
BACKGROUND AND OBJECTIVES Primary care databases form a unique source of population-based clinical information on the prevalence and management of diagnosed disorders. Historically such databases have lacked individual level socio-economic markers. We describe the development of the Doctors' Independent Network (DIN) database for epidemiological and health(More)
BACKGROUND Treatment with specific beta-blockers reduces mortality and hospitalisation in heart failure. AIM To describe trends and inequities in beta-blocker prescribing for heart failure. DESIGN OF STUDY Repeated cross-sectional analysis of a nationally representative primary care database (DIN-LINK). SETTING A total of 152 UK general practices. (More)
BACKGROUND The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource for epidemiological and health services research. GPRD (based on VAMP) presents notes as a series of discrete episodes, whereas DIN is(More)
TOPIC Electroconvulsive therapy (ECT) has become more common in the treatment of adults with refractory mood disorders and psychotic disorders but it remains one of the least common therapies for mental illness in children. In a small number of child psychiatry cases, symptoms are severe and unresponsive to standard pharmacological and other therapies. With(More)
The ovarian hormones, estradiol and progesterone, are believed to act at specific sites in the female brain to induce sexual receptivity. Septal lesions which have been comprehensively studied in the rat, were carried out on female hamsters. Lordosis behavior was quantified as an index of female sexual receptivity. Septal lesions were found to cause a(More)
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