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Scn2a-Null Heterozygosity Improves Survival and Modifies Neurocardiac Interaction in the Kcna1-Null Mouse Model of SUDEP
Analysis of EEG-ECG interaction dynamics revealed a significantly higher degree of association between brain and cardiac activity in double mutant mice compared to Kcna1-/- animals for several different measures, suggesting that Scn2a-null heterozygosity reduces SUDEP risk by altering neural control of the heart.