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Hepatocellular carcinoma (HCC) develops on the background of chronic hepatitis. Leukocytes found within the HCC microenvironment are implicated as regulators of tumour growth. We show that diethylnitrosamine (DEN)-induced murine HCC is attenuated by antibody-mediated depletion of hepatic neutrophils, the latter stimulating hepatocellular ROS and telomere(More)
iii Acknowledgements I would like to thank my thesis advisor Marc Freeman for all of his guidance and support and always having a box of tissues in his office. I am eternally grateful that he always believed in me and gave me the opportunity to perform my graduate work in his lab. I wish everyone had a mentor that was as optimistic and excited about science(More)
iii Acknowledgements I would like to thank my thesis advisor Marc Freeman for all of his guidance and support and always having a box of tissues in his office. I am eternally grateful that he always believed in me and gave me the opportunity to perform my graduate work in his lab. I wish everyone had a mentor that was as optimistic and excited about science(More)
iii Dedication This work is dedicated to my family: Paul Avery (father), Jill Avery (mother), Ryan Avery (brother), Bob Avery (grandfather), and Ruth Avery (grandmother) for all their support throughout my education and allowing me to believe I can do whatever I set my mind to. iv Acknowledgements First and foremost, I would like to thank my thesis advisor,(More)
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