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Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067(More)
Regulators of G protein signaling (RGS) are a family of proteins known to accelerate termination of effector stimulation after G protein receptor activation. RGS9-2, a brain-specific splice variant of the RGS9 gene, is highly enriched in striatum and also expressed at much lower levels in periaqueductal gray and spinal cord, structures known to mediate(More)
Genome-wide association analysis identifies 13 new risk loci for schizophrenia Abstract Schizophrenia is a heritable disorder with substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases, 6,243 controls) followed by meta-analysis with prior(More)
Transitivity in economics maintains that if a is preferred to b, and b to c, then a must also be preferred to c. The problem with this is that these three decisions are made at different points of time, and tastes may have changed in the interim. The difficulty with a rejection of transitivity (which underlies indifference curve analysis) is a reductio ad(More)
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