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BACKGROUND It is important to understand the nature of depression in non-Western and lower-income countries, but little such research exists. This study aimed to examine the characteristic features of depression in Sri Lanka, and to identify environmental risk factors. METHODS Depression diagnoses, symptoms and impairment were measured using the Composite(More)
BACKGROUND Case-control studies are vulnerable to selection and information biases which may generate misleading findings. AIMS To assess the quality of methodological reporting of case-control studies published in general psychiatric journals. METHOD All the case-control studies published over a 2-year period in the six general psychiatric journals(More)
The role of non-diagnostic features in the pathophysiology of autism spectrum disorders (ASDs) is unclear. Increasing evidence suggests immune system alterations in ASD may be implicated in the severity of behavioral impairment and other developmental outcomes. The primary objective of this meta-analysis was to investigate if there is a characteristic(More)
BACKGROUND Some motor vehicle crashes, particularly single-vehicle crashes, may result from intentional self-harm. We conducted a prospective cohort study to assess the risk that intentional self-harm poses for motor vehicle crashes among young drivers. METHODS We prospectively linked survey data from newly licensed drivers aged 17-24 years to data on(More)
BACKGROUND Fatigue is a common symptom in Western high-income countries but is often medically unexplained and little is known about its presentation in other populations. AIMS To explore the epidemiology and aetiology of fatigue in Sri Lanka, and of its overlap with depression. METHOD A total of 4024 randomly selected twins from a population-based(More)
BACKGROUND The nature of sleep-wake abnormalities in individuals with mental disorders remains unclear. The present study aimed to examine the differences in objective ambulatory measures of the sleep-wake and activity cycles across young people with anxiety, mood or psychotic disorders. METHODS Participants underwent several days of actigraphy(More)
BACKGROUND The outcome and impact of major depression in developing countries are not clear. AIMS To describe the outcome of major depression and compare the disability and patterns of service use among different outcome groups. METHOD In a case cohort study, nested within a population-based survey of 68,000 participants using the Composite(More)
AIM Early medical or behavioural intervention to slow cognitive decline might be a viable strategy for reducing disability and rates of institutional care in older persons. This paper details the published work supporting cross-sectional and longitudinal associations between vascular risk factors, depressive symptoms and progressive cognitive decline.(More)
BACKGROUND A considerable proportion of work absence is attributed to back pain, however prospective studies in working populations with back pain are variable in setting and design, and a quantitative summary of current evidence is lacking. OBJECTIVE To investigate the extent to which differences in setting, country, sampling procedures and methods for(More)
BACKGROUND Subjective memory complaints (SMC) are common but their significance is still unclear. It has been suggested they are a precursor of mild cognitive impairment (MCI) or dementia and an early indicator of cognitive decline. Vascular risk factors have an important role in the development of dementia and possibly MCI. We therefore aimed to test the(More)