Nick Nikolaides

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The gastric transepithelial potential difference seems to be a sensitive parameter of the integrity of gastric mucosa. The administration of acetylsalicylic acid in adults causes a rapid and significant decrease in gastric potential difference, whereas in children this characteristic reaction fails to occur.
The transmural potential difference (tpd) of the gastric mucosa was investigated in relation to age and sex of the patients. The administration of acetylsalicylic acid in healthy children causes no significant decrease in gastric potential difference. In children with acute of chronic inflammatory diseases (elevated blood sedimentation velocity) the tpd was(More)
The transmural electric potential difference (PD) of the gastric mucosa was investigated in children, teen-agers, and adults. Acetylsalicylic acid, a well known barrier breaker, causes in adults a characteristic decrease of the gastric PD. This effect in teen-agers is considerably weaker than in adults, while in children there is no significant decrease of(More)
The transepithelial potential difference of the gastrointestinal mucosa as a diagnostic parameter obtains increasing importance in clinical medicine. Therefore it is necessary to consider methodical aspects of the tPD-measurement under in-vivo conditions. The current paper presents methodical considerations for instance electrode arrangement, positions,(More)
A convenient preparation of 8-alkyl substituted 7-(2-imidazolinylamino)quinolines from the corresponding 8-trifluoromethanesulfonates, utilizing palladium cross-coupling reactions is described. During the course of our efforts to design and synthesize 2 adrenergic agonists, 8-ethyl-7-(2-imidazolinylamino)quinoline, 1, was identified as a potent and(More)
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