Nick M. Ward

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The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors acting to enhance the degree of activation of various 5-HT receptor subtypes. The 5-HT1A receptors are particularly relevant to the antidepressant and anxiolytic responses in(More)
Attention can be directed to a location in the absence of overt signs of orienting, a phenomenon termed "covert orienting." The ability to orient attention covertly has been well documented in humans, but recent progress has been made with the operational definition of the processes involved in covert orienting. Reaction times to visual targets are(More)
Evaluating the efficacy of neuroprotective drugs in rat models of focal cerebral ischemia has involved histological and behavioral batteries to examine treatment outcome. However, the behavioral tests used to date provide little insight into the nature of the neurological impairments. To provide an analysis of a possible "neglect" syndrome after occlusion(More)
 Focal cerebral ischemia in the rat has traditionally been studied by examining the consequences of middle-cerebral artery occlusion. However, the anterior-cerebral arteries of the rat may now also be bilaterally occluded by stereotaxic injection of the vasoconstrictor endothelin-1, resulting in ischemic damage to medial prefrontal cortex and the(More)
Damage to posterior parietal cortex in humans is known to cause hemineglect, and specifically difficulty in disengaging attention in tests of covert orienting. Aspirative lesions of a region of cortex in rats which is thought to be homologous to primate posterior parietal cortex has also been reported to cause what appears to be multimodal neglect. In order(More)
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