Nick Holford

Sara Bremer2
Elisabet Størset2
Karsten Midtvedt2
2Sara Bremer
2Elisabet Størset
2Karsten Midtvedt
2Stein Bergan
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To identify patient characteristics that influence tacrolimus individual dose requirement in kidney transplant recipients. Data on forty-four 12-h pharmacokinetic profiles from 29 patients and trough concentrations in 44 patients measured during the first 70 days after transplantation (1,546 tacrolimus whole blood concentrations) were analyzed. Population(More)
Sodium nitroprusside (SNP) has been widely used to control blood pressure in infants and children. The goals of this analysis were to develop models that describe the hemodynamic response to SNP dosing in pediatric patients; examine sources of variation in dose-response, defining age, and size dependencies; and determine vulnerable populations or patient(More)
In this paper, we present the implementation of a novel domain-specific language (DSL) for pharmacometric modeling called the Modelling Description Language (MDL). MDL is a modular, declarative language with block structures that allows users to abstract data, processes and mathematical models from auxiliary code, and hence, improves model readability,(More)
AIMS The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models. METHODS Data were obtained from 242 patients with 3100 tacrolimus whole blood concentrations. External evaluation was performed by examining model(More)
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